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Human BCMA x E. coli β-Gal Bispecific Antibody - Negative Control

Control scFv antibody - Recombinant

Evaluation of T cell activation

Absence of Jurkat-Lucia™ NFAT cell activation using Anti-hBCMA-βgal

Human TLR4 Dual Reporter HEK 293 Cells

NF-κB-SEAP & IRF-Lucia reporter cells

NF-κB responses of HEK-Blue™ hTLR4 vs. HEK-Dual™ hTLR4

NF-κB responses in hTLR4-expressing HEK-Dual™ -derived cells

IRF responses in hTLR4-expressing HEK-Dual™ -derived cells

Inhibition of TLR4-dependent NF-κB and IRF responses using CLI-095

Human TLR8 Dual Reporter HEK 293 Cells

NF-κB-SEAP and IRF-Lucia reporter cells

NF-κB response compared to HEK-Blue™ hTLR8

NF-κB responses in hTLR8-expressing HEK-Dual™-derived cells

IRF responses in hTLR8-expressing HEK-Dual™-derived cells

Recombinant Human CTLA-4-Fc Fusion Protein

Soluble human CTLA-4 (CD152) fused to an IgG1 Fc domain

hCTLA4-Fc analysis by SDS-PAGE

Cell surface staining using hCTLA4-Fc

ELISA detection of hCTLA4-Fc

Activation blockade of Jurkat-Lucia™ TCR-hPD-1 cells

Recombinant Human PD1-Fc Fusion Protein

Soluble human PD-1 (CD279) fused to an IgG1 Fc domain

hPD1-Fc analysis by SDS-PAGE

Cell surface staining using hPD1-Fc

ELISA detection of hPD1-Fc

Recombinant Human ICOS-L-Fc Fusion Protein

Soluble human ICOS-L (CD275) fused to an IgG1 Fc domain

hICOS-L-Fc analysis by SDS-PAGE

Cell surface staining using hICOS-L-Fc

ELISA detection of hICOS-L-Fc

Activation of Jurkat-Lucia™-hICOS cells

Recombinant Human ICOS-Fc Fusion Protein

Soluble human ICOS (CD278) fused to an IgG1 Fc domain

hICOS-Fc analysis by SDS-PAGE

Cell surface staining using hICOS-Fc

ELISA detection of hICOS-Fc

Jurkat & Raji CD27/CD70 Antagonist Assay (Bio-IC™)

Two cell line bioassay - B lymphocytes & NF-κB-Lucia reporter T lymphocytes

CD27 expression on Jurkat-Lucia™ hCD27 cells

CD70 expression on Raji-Null cells

Disruption of CD27/CD70 activatory interaction

Human EpCAM x E. coli β-Gal Bispecific Antibody - Negative Control

Control scFv antibody - Recombinant

Evaluation of T cell activation (ELISA)

Absence of Jurkat-Lucia™ NFAT cell activation using Anti-hEpCAM-βgal

Human EpCAM x Human CD3 Bispecific Antibody

Solitomab scFv antibody - Recombinant

Evaluation of T cell activation (ELISA)

Jurkat & Raji 4-1BB/4-1BBL Antagonist Assay (Bio-IC™)

Two cell line bioassay - B lymphocytes & NF-κB-Lucia reporter T Lymphocytes

4-1BB expression on Jurkat-Lucia™ h4-1BB cells

4-1BBL expression on Raji-Null cells

Disruption of 4-1BB/4-1BBL activatory interaction

Human IL-4Rα (CD124) Antibody - Dupilumab IgG1 Isotype

Human IgG1

Neutralization of cellular response to IL-4 and IL-13 using Anti-hIL-4R-hIgG1

Human EGFR-expressing Raji Cells

Human lymphoblast cells - ADCC EGFR Target Cells

Validation of hEGFR expression by flow cytometry

Comparison of ADCC potency for native and engineered anti-human EGFR antibody isotypes

IKK epsilon-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter human monocytes - IKKε deficient

Validation of IKKε KO by PCR and Western blot

Functional validation of IKKε knockout (NF-κB and IRF response)

RNA-induced responses in THP1-Dual™ KO-IKKε cells

Human TRIF-KO Dual Reporter THP-1 Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

Validation of TRIF KO

IRF responses in PMA-differentiated THP1-Dual™ KO-TRIF cells

NF-κB responses in PMA-differentiated THP1-Dual™ KO-TRIF cells

SARS-CoV-2 Spike expressing HEK293 cells

HEK293 SARS-CoV-2 Spike-expressing Cells

Cell fusion with 293-SARS-S cells

Spike detection in 293-SARS2-S-dfur Cells by flow cytometry

Human 4-1BB-expressing Raji Cells

Human lymphoblast cells - ADCC 4-1BB Target Cells

Validation of the expression of human 4-1BB by Raji-h4-1BB cells by flow cytometry

Comparison of ADCC potency for native and engineered anti-human 4-1BB antibody isotypes.

Human LAG3-expressing Raji Cells

Human lymphoblast cells - ADCC LAG3 Target Cells

Validation of the expression of human (h)LAG3 by Raji-hLAG3 cells.

Human ICOS-expressing Raji Cells

Human lymphoblast cells - ADCC ICOS Target Cells

Validation of the expression of human ICOS by Raji-hICOS cells by flow cytometry

ADCC assay using various anti-human ICOS antibody isotypes and Raji-hICOS target cells

#Cloning Vectors

ASC-GFP

ASC::GFP fusion gene

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