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CU-T12-9 - TLR2/TLR1 Agonist

Synthetic small molecule

CU-T12-9 triggers hTLR2 signaling

CU-T12-9 specifically activates hTLR2-TLR1

Specific activation of CU-T12-9 compared to other TLR2 ligands

Comparison of TLR2 heterodimer activation of synthetic TLR2 ligands

β-GlcCer - Mincle Agonist

C24:1 Glucosyl(β) Ceramide

β-GlcCer dose-dependent activation of Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

HKMT - Mincle & TLR2 Agonist

Heat-killed Mycobacterium tuberculosis

HKMT dose-dependent activation of TLR2 and Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

Pustulan - Dectin-1 Agonist

Beta-D-glucan from lichen Lasallia pustulata

Pustulan dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Pustulan

Scleroglucan - Dectin-1 Agonist

Beta-glucan from Sclerotium rolfsii

Scleroglucan dose-dependent activation of Dectin-1, TLR2, and TLR4

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Scleroglucan