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Anti-mMincle-IgG

Anti-mMincle-IgG Unit size Cat. code Docs Qty Price
Mouse Mincle Detection and Neutralizing antibody - Monoclonal Rat IgG2b
100 µg
mabg-mmcl
+-
$325.00

Mouse Mincle Detection and Neutralizing antibody - Monoclonal Rat IgG2b

Anti-mMincle-IgG is a monoclonal rat IgG isotype 2b antibody specific for mouse Mincle.

Mincle is a member of the Dectin-2 family.

Mincle recognizes a variety of exogenous and endogenous stimuli, such as mycobacteria, some fungi and necrotic cells.

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Specifications

Clonality: Monoclonal antibody

Applications: Neutralizing mincle-induced cellular activation. It can also be used for flow cytometry.

Specificity: Mouse Mincle

Isotype: Rat IgG2b

Clone: 6G5

Formulation: 0.2 μm filtered solution in PBS with 5% saccharose

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Contents

  • 100 μg purified monoclonal mMincle IgG antibody (Anti-mMincle-IgG), provided lyophilized

room temperature Product is shipped at room temperature.

store Store lyophilized anti-mMincle-IgG at -20°C.

stability Lyophilized anti-mMincle-IgG is stable for 1 year at -20°C. Resuspended anti-mMincle-IgG is stable up to 3 months when stored at -20°C.

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Description

Mincle recognizes a variety of exogenous and endogenous stimuli, such as mycobacteria, certain fungi and necrotic cells.

Exogenous ligands for Mincle include fungal α-mannose, and the mycobacterial glycolipid, trehalose-6’6’-dimycolate (TDM), also known as cord factor the immunostimulatory component of Mycobacterium tuberculosis.

Furthermore, Mincle senses damaged cells by recognizing the endogenous damage-associated molecular patterns (DAMPs). One such DAMP identified is the spliceosome-associated protein 130 (SAP130), a soluble factor released by necrotic cells.

Mincle interacts with the Fc receptor common γ-chain (FcRγ), which triggers intracellular signaling through Syk leading to CARD9-dependent NF-κB activation. Syk induces also the mobilization of intracellular calcium (Ca2+) and the activation of the calcineurin-NFAT pathway.

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Citations

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