Anti-hCD20-hIgG3
| Anti-hCD20-hIgG3 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Human CD20 (rituximab) antibody - Human IgG3 |
100 µg |
hcd20-mab3 |
You may also need : Anti-β-Gal-hIgG3 | View more associated products ▼
Monoclonal human IgG3 antibody against human CD20
Anti-hCD20-hIgG3 features the constant region of the human IgG3 isotype and the variable region of rituximab.
Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes.
Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity.
Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukaemia.
Anti-hCD20-hIgG3 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G.
Back to the top
Specifications
Clonality: Monoclonal antibody
Specificity: Targets cells expressing human CD20
Isotype: Human IgG3, kappa
Back to the topContents
- 100 µg purified anti-hCD20-hIgG3 antibody, provided azide-free and lyophilized.
Product is shipped at room temperature.
Store lyophilized antibody at -20°C.
Lyophilized product is stable for 1 year.