|pUNO1-mPGRPL||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the mouse PGRPL gene
Expression-ready ORF Clones
Alias : PGLYRP2
Peptidoglycan Recognition Protein, Long.
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that are conserved from insects to mammals and recognize bacteria and their unique cell wall component, peptidoglycan (PGN) . However, the consequences of this recognition are unknown, except in insects where PGRPs trigger the expression of antimicrobial peptides . Four mammalian PGRPs have been identified, PGRP-L, -S, -Ialpha, and -Ibeta, that are selectively expressed in different organs and have little homology outside the PGRP domains . This diversity suggests that binding of PGN to each PGRP may produce a different biological effect.
1. Dziarski R., 2004. Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 40(12):877-86.
2. Takehana A. et al., 2002. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A.99(21):13705-10.
3. Liu C. et al., 2001. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.J Biol Chem. 276(37):34686-94.
Mouse PGRPL (pUNO1-mPGRPL)
ORF size : 1593 bp
Subclone : AgeI - NheI
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20 ̊C.
Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.
Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.Back to the top