|pUNO1-hPGRPIA||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the human PGRPIA gene
Expression-ready ORF Clones
Alias : PGLYRP3
Peptidoglycan Recognition Protein I α.
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that are conserved from insects to mammals and recognize bacteria and their unique cell wall component, peptidoglycan (PGN) . However, the consequences of this recognition are unknown, except in insects where PGRPs trigger the expression of antimicrobial peptides . Four mammalian PGRPs have been identified, PGRP-L, -S, -Ialpha, and -Ibeta, that are selectively expressed in different organs and have little homology outside the PGRP domains . This diversity suggests that binding of PGN to each PGRP may produce a different biological effect.
1. Dziarski R., 2004. Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 40(12):877-86.
2. Takehana A. et al., 2002. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A.99(21):13705-10.
3. Liu C. et al., 2001. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.J Biol Chem. 276(37):34686-94.
Human PGRPIA (pUNO1-hPGRPIA)
Genbank : NM_052891.2
ORF size : 1026 bp
Subclone : AgeI - NheI
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.Back to the top