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PGRPIA (PGLYRP3)

pUNO1-hPGRPIA Unit size Cat. code Docs Qty Price
pUNO1 bearing the human PGRPIA gene
20 µg
puno1-hpgrp1a
+-
$384.00

Expression-ready ORF Clones

Alias : PGLYRP3

 

Peptidoglycan Recognition Protein I α.

 

Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that are conserved from insects to mammals and recognize bacteria and their unique cell wall component, peptidoglycan (PGN) [1]. However, the consequences of this recognition are unknown, except in insects where PGRPs trigger the expression of antimicrobial peptides [2]. Four mammalian PGRPs have been identified, PGRP-L, -S, -Ialpha, and -Ibeta, that are selectively expressed in different organs and have little homology outside the PGRP domains [3]. This diversity suggests that binding of PGN to each PGRP may produce a different biological effect.

1. Dziarski R., 2004. Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 40(12):877-86.
2. Takehana A. et al., 2002. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A.99(21):13705-10.
3. Liu C. et al., 2001. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.J Biol Chem. 276(37):34686-94. 

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Specifications

Human PGRPIA (pUNO1-hPGRPIA)

Genbank : NM_052891.2
ORF size : 1026 bp
Subclone : AgeI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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