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Murine Anti-mIL-13 mAb

Anti-mIL-13-IgG Unit size Cat. code Docs Qty Price
Mouse IL-13 Neutralizing Antibody - Monoclonal Mouse IgG1 (8H8)
100 µg
5 x 100 μg
mabg-mil13
+-
$285.00

Neutralizing monoclonal antibody against murine interleukin 13

Neutralizing monoclonal antibody against murine IL-13
Neutralizing monoclonal antibody against murine IL-13

Anti-mIL-13-IgG is a fully mouse monoclonal antibody (mAb) specific for murine interleukin 13 (mIL-13). This auto-antibody was raised in mice by a proprietary method designed to induce the production of anti-cytokine antibodies directly in the animal. It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neutralize the biological activity of mIL-13. IL-13 is a multifunctional cytokine that plays an important role in the regulation of inflammation and immune responses [1, 2].

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Key features:

  • A potent and specific neutralizing mAb against mIL-13
  • Provided azide-free
  • No cross-reactivity with human IL-13
  • Each lot is functionally tested

 

References:

1. Kasaian M.T. et al., 2013. An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice. Am J Respir Cell Mol Biol.49(1):37-46.
2. David M. et al., 2003. Functional characterization of IL-13 receptor a2 gene promoter: a critical role of the transcription factor STAT6 for regulated expression. Oncogene 22, 3386-94.

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Specifications

Target: natural and recombinant mouse interleukin 13 (mIL-13)
Specificity: no cross-reactivity with human IL-13
Clone: 8H8
Isotype: Mouse IgG1, kappa
Control: Mouse IgG1
Immunogen: Mouse IL-13 protein expressed in Swiss mice following DNA immunization
Formulation: 0.2 µm filtered solution in a sodium phosphate buffer with glycine, saccharose, and stabilizing agents
Tested applications: Blocking & Neutralisation

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Contents

Anti-mIL-13-IgG purified antibody is provided azide-free and lyophilized. It is available in two pack sizes:

  • 100 µg: mabg-mil13
  • 5 x 100 µg: mabg-mil13-5

 

room temperature The product is shipped at room temperature.

store Upon receipt, store lyophilized antibody at -20 °C.

stable Reconstituted antibody is stable for 1 month at 4 °C and for 1 year at -20 °C.

Alert Avoid repeated freeze-thaw cycles.

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Details

Interleukin 13 (IL-13) is a cytokine that plays an important role in regulating inflammation and immune responses [1]. It is produced mainly by activated T cells. IL-13 exerts its anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines, such as TNF‑α. The biological functions of IL-13 overlap with those of interleukin 4 (IL-4). In fact, both IL-4 and IL-13 can bind to the same receptor complex, IL-13 receptor (IL-13R), which is composed of two subunits IL-4Rα and IL-13Rα1 [2]. The binding of IL-­4 or IL-13 to IL-13R instigates a signaling cascade involving the activation of receptor-associated Janus kinases (JAK1 and Tyk2) and the nuclear translocation of STAT6. The nuclear translocation of STAT6 ultimately leads to the induction of gene expression by IL-13 [3].

 

1. Kasaian M.T. et al., 2013. An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice. Am J Respir Cell Mol Biol.49(1):37-46.
2. David M. et al., 2003. Functional characterization of IL-13 receptor a2 gene promoter: a critical role of the transcription factor STAT6 for regulated expression. Oncogene 22, 3386-94.
3. Dickensheets H.L. et al., 1999. Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. PNAS. 96(19):10800-5.

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Citations

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