STING (stimulator of interferon genes), alternatively known as MPYS, TMEM173, MITA and ERIS, is a key sensor of cytosolic nucleic acids.
STING, initially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), was recently found to be a direct sensor of cyclic dinucleotides (CDNs).
Interestingly, a variety of natural variants of human STING (hSTING) have been identified. The presence of nonsynonymous variants of hSTING, some in high frequencies is indicative of its implicit role in disease.
It is important to be aware that variant hSTING alleles differentially respond to cGAMPs.
InvivoGen offers a set of tools to study STING signaling pathway:
- Cyclic dinucleotides, recently found to bind to and activate STING
- STING Reporter cells
- STING variants, cloned and fully-sequenced into an expression plasmid