RAW 264.7 macrophages

RAW 264.7 cells are a macrophage-like, Abelson leukemia virus transformed cell line derived from BALB/c mice. This cell line is a commonly used model of mouse macrophages for the study of cellular responses to microbes and their products.

InvivoGen has developed RAW-Blue cells and RAW-Lucia cells, which express a secreted inducible reporter gene to monitor the activation of the NF-κB or interferon regulatory factor (IRF) pathway.

RAW-Blue cells express the secreted alkaline phosphatase (SEAP) reporter gene. RAW-Lucia™ cells express the Lucia luciferase reporter gene.

A collection of knockout cell lines has been generated in the RAW-Lucia™ ISG cell line for genes involved in the recognition of nucleic acids. The knockout genotype of these cell lines is guaranteed. The frameshift mutation/delection on both alleles of the target gene has been verified by DNA sequencing.

NF-κB-Reporter Cells

RAW-Blue™ CellsNF-κB-SEAP Reporter Cell Line3-7 x 10e6 cells

IRF-Reporter Cells

RAW-Blue™ ISG CellsIRF-SEAP-Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG CellsIRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells

IRF/KIN-MIP2 -Reporter Cells

RAW-Dual™ CellsDual IRF and KIN-MIP-2 (NF-kB) Reporter Cell Line3-7 x 10e6 cells

Knockout Cells

RAW-Lucia™ ISG-KO-cGAS CellscGAS Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-IFI16 CellsIFI16 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-IRF3 CellsIRF3 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-IRF7 CellsIRF7 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-MAVS Cells NEWMAVS-Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-MDA5 CellsMDA-5 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-RIG-I CellsRIG-I Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-STING CellsSTING Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-TBK1 CellsTBK1 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-TREX1 CellsTREX1 Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-TRIF CellsTRIF Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells

Autophagy Reporter Cells

RAW-Difluo™ mLC3 Cells NEWAutophagy Reporter Cells3-7 x 10e6 cells
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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