NOD1 (CARD4) and NOD2 (CARD15) are two members of the growing family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.
NOD1 and NOD2 are intracellular pattern-recognition molecules involved in the recognition of peptidoglycan (PGN). They detect specific motifs within the PGN. NOD1 senses the iE-DAP dipeptide which is found in PGN of all Gram-negative and certain Gram-positive bacteria whereas NOD2 recognizes the muramyl dipeptide (MDP) structure found in almost all bacteria.
InvivoGen provides PGNs from Gram-negative and Gram-positive bacteria, and bioactive fragments of PGN, such as iE-DAP and MDP. The functionality of these NOD ligands are validated using HEK-Blue™ NOD1 and HEK-Blue™ NOD2 Cells.