NOD Ligands

NOD1 (CARD4) and NOD2 (CARD15) are two members of the growing family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.

NOD1 and NOD2 are intracellular pattern-recognition molecules involved in the recognition of peptidoglycan (PGN). They detect specific motifs within the PGN. NOD1 senses the iE-DAP dipeptide which is found in PGN of all Gram-negative and certain Gram-positive bacteria whereas NOD2 recognizes the muramyl dipeptide (MDP) structure found in almost all bacteria.

InvivoGen provides PGNs from Gram-negative and Gram-positive bacteria, and bioactive fragments of PGN, such as iE-DAP and MDP. The functionality of these NOD ligands are validated using HEK-Blue™ NOD1 and HEK-Blue™ NOD2 Cells.


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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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