NOD1 Agonists

iE-DAP and Derivatives


NOD1 (CARD4) is a member of the family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats. NOD1 is an intracellular pattern-recognition molecule involved in the recognition of peptidoglycan (PGN). NOD1 senses the iE-DAP dipeptide which is found in PGN of all Gram-negative and certain Gram-positive bacteria.

InvivoGen provides iE-DAP, the minimal motif recognized by NOD1, and iE-DAP derivatives that stimulate NOD1 at concentrations lower than the original iE-DAP. The functionality of these NOD1 ligands is validated using HEK-Blue™ NOD1 Cells.

C12-iE-DAPNOD1 Agonist - Acylated derivative of iE-DAP1 mg
C14-Tri-LAN-Gly NEWNOD1 Agonist - Meso‑lanthionine tri-peptide1 mg
iE-DAPNOD1 Agonist - D-gamma-Glu-mDAP5 mg
iE-LysNegative control for iE-DAP5 mg
Tri-DAPNOD1 Agonist - L-Ala-gamma-D-Glu-mDAP1 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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