NOD-Like Receptors - NLRs

NOD-Like Receptors (NLRs) constitute a family of intracellular pattern recognition receptors (PRRs), which contains more than 20 members in mammals. Their primary role is to recognize cytoplasmic pathogen-associated molecular patterns (PAMPs) and/or endogenous danger signal, inducing immune responses.
NLRs are characterized by a tripartite-domain organization with a conserved nucleotide binding oligomerization domain (NOD) and leucine-rich repeats (LRRs).

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InvivoGen offers a large set of tools to study the NLRs, in particular the NOD1 and NOD2 signaling pathways: NOD reporter cell lines, NOD ligands, shRNAs as NLR inhibitors, and fully sequenced NLR and related genes.

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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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