CLR Ligands

Schematic representation of the Dectin-1 major isoformsDectin-1, Dectin-2, and Mincle Agonists

Dectin-1 is a specific receptor of β-glucans, which are glucose polymers found in the cell walls of fungi, including the yeasts Saccharomyces cerevisiae and Candida albicans.
All Dectin-1 ligands are tested for Dectin-1 stimulation using Raw-Blue™ reporter cells.

Dectin-2 binds to mannose carbohydrates, such as the mannose-capped lipoarabinomannan of mycobacteria and α-mannans found in Candida albicans.

Mincle is a multi-task danger receptor that recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria.

Dectin-1 Agonists

Beta-glucan peptide (BGP)Dectin-1 Agonist - Beta-glucan from Trametes versicolor50 mg
CurdlanDectin-1 Agonist - Beta-1,3-glucan from A. faecalis1 g
HKCADectin-1 Agonist - Heat-killed C. albicans10e9 cells
LaminarinDectin-1 ligand -Soluble beta-glucan from Laminaria digitata100 mg
PustulanDectin-1 Agonist - Beta-D-glucan from lichen Lasallia pustulata100 mg
SchizophyllanDectin-1 Agonist - Beta-glucan from Schizophyllum commune100 mg
ScleroglucanDectin-1 Agonist - Beta-glucan from Sclerotium rolfsii100 mg
WGP DispersibleDectin-1 Agonist - Whole Glucan Particles, insoluble50 mg
WGP SolubleWGP control / Dectin-1 inhibitor - Whole Glucan Particles, soluble50 mg
ZymosanTLR2 Agonist - Dectin-1 Agonist - Cell wall preparation of S. cerevisiae100 mg
Zymosan DepletedDectin-1 Agonist - Hot alkali treated zymosan10 mg

Dectin-2 Agonist

FurfurmanDectin-2 agonist - Malassezia furfur cell wall preparation10 mg

Mincle Agonist

HKMTMincle Agonist - TLR2 Agonist - Heat-killed Mycobacterium tuberculosis 10 mg
50 mg
TDBMincle Agonist - Synthetic analog of the cord factor2 mg
TDB VacciGrade™Mincle agonist - Synthetic analog of the cord factor
Th1 response
2 mg
TDB-HS15Mincle Agonist - Synthetic cord factor analog formulated with HS152 mg
TDM NEWMincle Agonist - Trehalose-6,6-dimycolate2 mg
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