Inflammasome Test Cells
THP-1 human monocytic cells are the most commonly used model cell line for studying inflammasome activation. They express high levels of NLRP3, ASC and pro-caspase-1.
InvivoGen provides engineered THP-1 cells that express reduced levels of NLRP3 or ASC and a new CASP-1 knockdown cell line.
All of these cell lines are useful for determining whether a signal activates the inflammasome, in particular the NLRP3 inflammasome.