NLR and Related Genes

NOD-Like Receptors (NLRs, also known as CATERPILLERs) constitute a family of intracellular pattern recognition receptors (PRRs) that recognize cytoplasmic pathogen-associated molecular patterns (PAMPs) and/or endogenous danger signal.

NLRs are comprised of three distinct functional domains:

• an N-terminal effector domain involved in signaling
• a centrally located regulatory NOD domain
• a C-terminal LRRs serving as a ligand-recognition domain

NLRs have been grouped into several subfamilies on the basis of their effector domains:

• CARD subfamily includes NODs and IPAF
• Pyrin (PYD) subfamily consists of the NALPs
• BIR subfamily comprises the NAIPs

InvivoGen provides a selection of NLR genes as well as numerous genes involved in the NLR pathways cloned in an expression plasmid.