Antibody Generation


Isotype switch to generate antibodies with different effector functions ( IgA, IgD, IgE, IgG and IgM classes)
▶ Generation of entire antibodies, chimeric, humanized or fully human

pFUSE-CLIg and pFUSE-CHIg plasmids are designed to change a monoclonal antibody from one isotype to another therefore enabling the generation of antibodies with the same antigen affinity but with different effector functions (increased or reduced ADCC and CDC).
Furthermore, they can be used to produce entire antibodies from fragment antigen-binding (Fab) or single-chain variable fragment (scFv) fragments that are either chimeric, humanized or fully human depending on the nature of the variable region.

More Info on IgG

Antibody Generation

pFUSE-CLIgCloning plasmids with constant region of the light (CL) chain
pFUSE-CHIgCloning plasmids with constant regions of the heavy (CH) chain
pFUSE-Lucia-CHIgCloning plasmids with constant regions of the heavy (CH) chain and a secreted luciferase gene
Engineered pFUSE-CHIgCloning plasmids with mutant constant regions of IgHG1
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".