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• Cloning & Expression Vectors

  • psiRNA™ Vectors

  • Antibody Generation

    • pFUSE-CLIg

    • pFUSE-CHIg

    • Engineered pFUSE-CHIg

  • Fc-Fusion

  • Rodent Transgenesis

  • Expression Plasmids

  • DNA Vaccination

  • CpG-free Plasmids

  • Lentivirus Production

  • Sequencing Primers

Literature

Antibody Generation

pFUSE-CLIg and pFUSE-CHIg

• Isotype switch to generate IgG antibodies with different effector functions
• Generation of entire IgG antibodies, chimeric, humanized or fully human

pFUSE-CLIg and pFUSE-CHIg plasmids are designed to change a monoclonal antibody from one isotype to another human or murine IgG isotype therefore enabling the generation of antibodies with the same antigen affinity but with different effector functions (increased or reduced ADCC and CDC).
Furthermore, they can be used to produce entire IgG antibodies from fragment antigen-binding (Fab) or single-chain variable fragment (scFv) fragments that are either chimeric, humanized or fully human depending on the nature of the variable region.

More Info on IgG