TLR5 Ligands

Toll-like receptor 5 (TLR5) recognizes flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR participating in flagellin recognition. However, TLR5 may require the presence of a co-receptor or adaptor molecule for efficient ligand recognition and/or signaling.

InvivoGen provides flagellin purified from B.subtilis (Gram+) and S.typhimurium (Gram-) bacteria and a new recombinant form. Flagellin FliC VacciGrade™ (preclinical grade: sterile and endotoxin level HEK-Blue™ TLR5 Cells are used to validate the functionality of the TLR5 ligands.


FLA-BS (Standard or Ultrapure)TLR5 Agonist - Flagellin from B. subtilis Ultrapure (50 µg)
Standard (100 µg)
FLA-PA UltrapureTLR5 Agonist - Flagellin from P. aeruginosa50 µg
FLA-ST (Standard or Ultrapure)TLR5 Agonist - Flagellin from S. typhimurium Ultrapure (50 µg)
Standard (100 µg)
Ultrapure (10 µg)
Rec FLA-STTLR5 Agonist - Recombinant flagellin from S. typhimurium 10 µg
50 µg
Flagellin FliC VacciGrade™TLR5 Agonist - Recombinant flagellin
Th1/Th2 response
50 µg


hTLR5-FcSoluble ectodomain of human TLR5 - TLR5 inhibitor50 µg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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