Inflammasome Inducers

The inflammasome is a multi-protein complex involved in the production of mature IL-1β. It is activated by a large variety of microbial molecules, danger signals and crystalline substances.

InvivoGen introduces inflammasome inducers, molecules that induce caspase-1 activation and IL-1β maturation by triggering the assembly of the NLRP3 or AIM2 inflammasome protein complexes. They act through various mechanisms, such as induction of cytosolic potassium efflux or phagosomal destabilization. We also offer inhibitors to confirm the ability of a given molecule to activate the inflammasome or to test the importance of phagocytosis or potassium efflux in this process. These inflammasome inducers and inhibitors have been validated using the IL-1β sensor cell line.

Canonical Inflammasome Inducers - NLRP3 Inflammasome

Alum CrystalsNLRP3 Inflammasome Inducer - Aluminium potassium sulfate1 g
ATPNLRP3 Inflammasome Inducer - Adenosine 5'-triphosphate disodium salt1 g
Chitosan UltrapureNLRP3 Inflammasome Inducer - Deacetylated derivative of chitin100 mg
Chitosan VacciGrade™NLRP3 inflammasome inducer - Deacetylated derivative of chitin
Th1/Th2 response
100 mg
CPPD CrystalsNLRP3 Inflammasome Inducer - Calcium Pyrophosphate Dihydrate crystals5 mg
HemozoinNLRP3 Inflammasome Inducer - Synthetic heme crystal5 mg
MSU CrystalsNLRP3 Inflammasome Inducer - Monosodium Urate Crystals 5 mg
25 mg
Nano-SiO2NLRP3 Inflammasome Inducer - Nanoparticles of silica dioxide10 mg
NigericinNLRP3 Inflammasome Inducer - Nigericin, sodium salt 10 mg
50 mg
TDBMincle Agonist - Synthetic analog of the cord factor2 mg

Canonical Inflammasome Inducers - AIM2 Inflammasome

Poly(dA:dT)RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer 200 µg
1 mg
Poly(dA:dT) / LyoVec™RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer - complexed with transfection reagent100 µg
Poly(dA:dT) RhodamineRIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer - Rhodamine labeled10 µg

Canonical Inflammasome Inducers - NLRC4 Inflammasome

FLA-PA UltrapureTLR5 Agonist - Flagellin from P. aeruginosa50 µg
FLA-ST (Standard or Ultrapure)TLR5 Agonist - Flagellin from S. typhimurium Ultrapure (50 µg)
Standard (100 µg)
Ultrapure (10 µg)

Canonical Inflammasome Inducers - NLRP1 Inflammasome

L18-MDPNOD2 Agonist - Muramyldipeptide with a C18 fatty acid chain1 mg
MDPNOD2 Agonist - Muramyldipeptide (L isoform)5 mg

Non-canonical Inflammasome Inducers

CurdlanDectin-1 Agonist - Beta-1,3-glucan from A. faecalis1 g
HKCADectin-1 Agonist - Heat-killed C. albicans10e9 cells
PustulanDectin-1 Agonist - Beta-D-glucan from lichen Lasallia pustulata100 mg
Zymosan DepletedDectin-1 Agonist - Hot alkali treated zymosan10 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".