Inflammasome Inducers

The inflammasome is a multi-protein complex involved in the production of mature IL-1β. It is activated by a large variety of microbial molecules, danger signals and crystalline substances.

InvivoGen introduces inflammasome inducers, molecules that induce caspase-1 activation and IL-1β maturation by triggering the assembly of the NLRP3 or AIM2 inflammasome protein complexes. They act through various mechanisms, such as induction of cytosolic potassium efflux or phagosomal destabilization. We also offer inhibitorsto confirm the ability of a given molecule to activate the inflammasome or to test the importance of phagocytosis or potassium efflux in this process. These inflammasome inducers and inhibitors have been validated using the IL-1β sensor cell line.

Canonical Inflammasome Inducers - NLRP3 Inflammasome

Alum Crystals NLRP3 Inflammasome Inducer - Aluminium potassium sulfate 1 g
ATP NLRP3 Inflammasome Inducer - Adenosine 5'-triphosphate disodium salt 1 g
Chitosan Ultrapure NLRP3 Inflammasome Inducer - Deacetylated derivative of chitin 100 mg
Chitosan VacciGrade™ NLRP3 inflammasome inducer - Deacetylated derivative of chitin
Th1/Th2 response
100 mg
CPPD Crystals NLRP3 Inflammasome Inducer - Calcium Pyrophosphate Dihydrate crystals 5 mg
Hemozoin NLRP3 Inflammasome Inducer - Synthetic heme crystal 5 mg
MSU Crystals NLRP3 Inflammasome Inducer - Monosodium Urate Crystals 5 mg
25 mg
Nano-SiO2 NLRP3 Inflammasome Inducer - Nanoparticles of silica dioxide 10 mg
Nigericin NLRP3 Inflammasome Inducer - Nigericin, sodium salt 10 mg
50 mg
TDB Mincle Agonist - Synthetic analog of the cord factor 2 x 1 mg

Canonical Inflammasome Inducers - AIM2 Inflammasome

Poly(dA:dT) RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer 200 µg
1 mg
Poly(dA:dT) / LyoVec™ RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer - complexed with transfection reagent 100 µg
Poly(dA:dT) Rhodamine RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer - Rhodamine labeled 10 µg

Canonical Inflammasome Inducers - NLRC4 Inflammasome

FLA-PA Ultrapure TLR5 Agonist - Flagellin from P. aeruginosa 50 µg
FLA-ST (Standard or Ultrapure) TLR5 Agonist - Flagellin from S. typhimurium Ultrapure (50 µg)
Standard (100 µg)
Ultrapure (10 µg)

Canonical Inflammasome Inducers - NLRP1 Inflammasome

L18-MDP NOD2 Agonist - Muramyldipeptide with a C18 fatty acid chain 1 mg
MDP NOD2 Agonist - Muramyldipeptide (L isoform) 5 mg

Non-canonical Inflammasome Inducers

Curdlan AL Dectin-1 Agonist - Beta-1,3-glucan from A. faecalis 1 g
HKCA Dectin-1 Agonist - Heat-killed C. albicans 10e9 cells
Pustulan Dectin-1 Agonist - Beta-D-glucan from lichen Lasallia pustulata 100 mg
Zymosan Depleted Dectin-1 Agonist - Hot alkali treated zymosan 10 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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