MSU Crystals

Monosodium Urate Crystals - NLRP3 inflammasome Inducer

Monosodium urate (MSU) or uric acid is the aetiological agent of the acute inflammatory condition gout.

MSU crystals induce inflammation by triggering the production of the highly inflammatory cytokine interleukin (IL)-1β.
Indeed, cells from the human monocytic cell line THP-1 or primary monocytes secrete IL-1β after stimulation with MSU crystals [1].

MSU-induced IL-1β production was recently shown to require the NLRP3 (also known as NALP3 or cryopyrin) inflammasome. The NLRP3 inflammasome is a caspase-1-activating complex comprising the NLR protein NLRP3 and the adaptor ASC required for the maturation and secretion of IL-1β [2]. Involvement of the inflammasome is suggested by the finding that macrophages from mice deficient in various components of the inflammasome are defective in crystal-induced IL-1β induction [1].


Working concentration: 50 - 200 µg/ml
CAS number:
Linear formula:
Molecular weight:
Triclinic crystals characterized by X-ray diffraction
Not soluble


Monosodium urate (MSU) crystals are available in two quantities:
- 5 mg: tlrl-msu
- 25 mg: tlrl-msu-25

MSU crystals are shipped at room temperature. Store at 4 °C for 1 year.


1. Martinon F. et al., 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 440(7081):237-41.
2. Martinon F, Tschopp J., 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 117(5):561-74.


MSU Crystals

Description Monosodium Urate Crystals
Cat. Codetlrl-msu
Unit Size5 mg
Price For price or distributor address,
please select your country

MSU Crystals

Description Monosodium Urate Crystals
Cat. Codetlrl-msu-25
Unit Size25 mg
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".