SiO2 nanoparticles (Nano-SIO2) are single particles of silica dioxide, an inorganic metal oxide, with a diameter less than 100 nm.

Nano-SiO2 was recently shown to trigger caspase-1 cleavage and IL-1β secretion in human macrophages and keratinocytes [1]. The pro-inflammatory activity of nano-SiO2 is mediated by the NLRP3 inflammasome. THP1 cells stably infectected with shRNAs against caspase-1 or NLRP3 did not secrete IL-1β in response to nano-SiO2.


Working concentration: 10-200 µg/ml

CAS number: 7631-86-9

Linear formula: SiO2

Molecular weight: 60.08

Purity: ≥99%

Solubility: Not soluble


10 mg Nano-SiO2 (nanoparticles of silicon dioxide)

Nano-SiO2 is shipped at room temperature. Store at room temperature.


1. Yazdi AS. et al., 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. PNAS. 107(45):19449-54


Recent articles using InvivoGen Nano-SiO2



Description NLRP3 Inflammasome Inducer
Cat. Codetlrl-sio
Unit Size10 mg
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