STING Reporter Cells

STING ligands trigger the production of type I IFNs and the induction of interferon stimulated genes (ISG) through interferon regulatory factors (IRFs).

In order to facilitate their study, InvivoGen has developed two types of stable reporter cells:
- Cells in which STING has been knocked out or knocked down. 
- Cells where the wild-type STING gene has been replaced by a STING variant (wild type STING knocked out, followed by a variant STING knocked-in).

These cells are either of human or mouse origin, and feature IRF-inducible secreted reporter proteins SEAP (secreted embryonic alkaline phosphatase) and/or Lucia luciferase as convenient read-outs.

THP1

THP1-Blue™ ISG CellsHuman THP-1 Monocytes - IRF SEAP Reporter3-7 x 10e6 cells
THP1-Dual™ KO-STING CellsHuman THP-1 Monocytes - STING knockout NF-κB-SEAP and IRF-Lucia Reporter Cells3-7 x 10e6 cells
THP1-Dual™ KI-hSTING-S154 Cells NEWHuman THP-1 Monocytes - STING (S154 isoform; constitutively active) knockin NF-kB-SEAP and IRF-Lucia Reporter Cells3-7 x 10e6 cells
THP1-Dual™ KI-hSTING-A162 CellsHuman THP-1 Monocytes - STING (A162 isoform) knockin NF-kB-SEAP and IRF-Lucia Reporter Cells3-7 x 10e6 cells
THP1-Dual™ KI-hSTING-R232 CellsHuman THP-1 Monocytes - STING (R232 isoform) knockin NF-kB-SEAP and IRF-Lucia Reporter Cells3-7 x 10e6 cells

293T

293T-Dual™ hSTING-A162 Cells NEWDual IRF and IFN-β reporter 293T cells expressing A162 isoform of human STING (S162A)3-7 x 10e6 cells
293T-Dual™ hSTING-H232 Cells NEWDual IRF and IFN-β reporter 293T cells expressing H232 isoform of human STING (R232H)3-7 x 10e6 cells
293T-Dual™ hSTING-R232 Cells NEWDual IRF and IFN-β reporter 293T cells expressing R232 isoform of human STING3-7 x 10e6 cells
293T-Dual™ mSTING Cells NEWDual IRF and IFN-β reporter 293T cells expressing murine STING3-7 x 10e6 cells
293T-Dual™ Null Cells NEWDual IRF and IFN-β reporter 293T cells3-7 x 10e6 cells

HEK293

HEK-Blue™ ISG CellsInterferon Regulatory Factor (IRF)-Inducible SEAP Reporter HEK293 Cells3-7 x 10e6 cells
HEK-Blue™ ISG-KO-STING CellsSTING Knockout IRF Reporter Cell Line3-7 x 10e6 cells

B16

B16-Blue™ ISG CellsMurine B16 melanoma - IFNs reporter cells3-7 x 10e6 cells
B16-Blue™ ISG-KO-STING CellsMurine B16 melanoma - STING Knockout IRF-reporter cells3-7 x 10e6 cells

RAW 264.7

RAW-Lucia™ ISG CellsIRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
RAW-Lucia™ ISG-KO-STING CellsSTING Knockout IRF-Lucia Luciferase Reporter Cell Line3-7 x 10e6 cells
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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