Toll-like receptor 2 (TLR2) is involved in the recognition of a wide array of microbial molecules representing broad groups of species such as Gram-positive and Gram-negative bacteria, as well as mycoplasma and yeast. TLR2 recognizes cell-wall components such as peptidoglycan, lipoteichoic acid and lipoprotein from gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall. The variety of TLR2 ligands is the greatest among all the TLRs and this is due to the heterodimerization needed for TLR2-mediated responses.
InvivoGen provides heat-killed bacteria and several cell-wall components which have been identified as TLR2 ligands. HEK-Blue™ TLR2 Cells are used to validate the functionality of these TLR ligands.