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• Cloning & Expression Vectors

  • psiRNA™ Vectors

  • Antibody Generation

  • Fc-Fusion

    • pFUSE-Fc Vectors

    • pINFUSE-Fc Vectors

    • Engineered Fc pFUSE-Fc Vectors

    • pFUSE-SEAP-Fc

  • Rodent Transgenesis

  • Expression Plasmids

  • DNA Vaccination

  • CpG-free Plasmids

  • Lentivirus Production

  • Sequencing Primers

Literature

Fc-Fusion

pFUSE-Fc

• Large choice of Fc regions from different species: human, mouse, rat and rabbit
• Fc regions without intron (pFUSE-Fc) or with introns (pINFUSE-Fc)
• Native Fc regions or engineered Fc regions with altered effector functions

pFUSE-Fc is a family of plasmids developed to facilitate the construction of Fc-Fusion proteins by fusing a sequence encoding a given protein to the Fc region of an immunoglobulin.
The Fc-fusion proteins are called immunoadhesins when the Fc region is combined with the functional domain of a binding protein, such as a receptor, ligand or cell-adhesion molecule. The Fc region comprises the CH2 and CH3 domains of the IgG heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-Fusion protein, allowing each part of the molecule to function independently.