CpG-free Genes

Synthetic CpG-free Genes

Many non-mammalian genes are widely used as reporter or suicide genes in molecular and cellular studies. However these genes are recognized as foreign DNA by the vertebrate host leading to a progressive decline of their expression. To circumvent this limitation, InvivoGen has synthesized new alleles of these genes completely devoid of CpG dinucleotides. These synthetic CpG-free genes display higher activity and lower immunogenicity than their wild-type counterparts.

CpG-free Reporter genes

CpG-free GFP::ShSynthetic reporter / resistance fusion gene in expression plasmid20 µg
CpG-free GFP::BsrSynthetic reporter / resistance fusion gene in expression plasmid20 µg
CpG-free LacZSynthetic LacZ reporter gene in expression plasmid20 µg
CpG-free LacZnlsSynthetic LacZ reporter gene with SV40 nuclear localization signal in expression plasmid20 µg
CpG-free LacZ::ShSynthetic reporter / resistance fusion gene in expression plasmid20 µg
CpG-free Luc::ShSynthetic reporter / resistance fusion gene in expression plasmid20 µg
CpG-free SEAPSynthetic SEAP reporter gene in expression plasmid 20 µg
20 µg

CpG-free Cytotoxic genes

CpG-free Fcy::furSynthetic cytotoxic CD::UPRT fusion gene in expression plasmid20 µg
CpG-free HSV1-tkSynthetic cytotoxic viral TK gene in expression plasmid20 µg
CpG-free HSV1-tk::ShSynthetic cytotoxic / resistance fusion gene in expression plasmid20 µg

CpG-free Resistance genes

Low-CpG PacSynthetic Puromycin resistance gene in cloning plasmid20 µg
Low-CpG BsrSynthetic Blasticidin resistance gene in cloning plasmid20 µg
CpG-free hphSynthetic Hygromycin resistance gene in cloning plasmid20 µg
CpG-free Sh bleSynthetic Zeocin resistance gene in cloning plasmid20 µg
CpG-free neoSynthetic Neomycin resistance gene in cloning plasmid20 µg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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