CpG-free HSV1-tk

Suicide genes code for enzymes, such as thymidine kinases (TKs), that convert non-toxic compounds (prodrugs) into toxic products.

Invivogen provides the thymidine kinase gene from Herpes simplex virus type 1 (HSV1) that codes for TKs, an enzyme able to convert nucleoside analogs such as ganciclovir (GCV) into cytotoxic molecules. The DNA sequence of this viral gene was modified by humanizing the codon usage and eliminating all the CpGs. The synthetic HSV1-tk gene is provided in the expression plasmid pSelect-zeo which is selectable with Zeocin™ in both mammalian and E.coli cells.


Gene: CpG-free HSV1-tk
Description: Synthetic herpes simplex virus 1 (HSV1) thymidine kinase (TK) gene
Backbone: pSELECT-zeo
Selection: Zeocin

121 CpG in native gene


• 20 μg of pSELECT-zeo-HSV1-tk plasmid provided as lyophilized DNA
• 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)


Recent articles using InvivoGen CpG-free HSV1-tk



Cat. Codepsetz-hsv1tk
Unit Size20 µg
Price For price or distributor address,
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Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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