NOD2 Agonists

MDP and Derivatives

MDP (MurNAc-L-Ala-D-isoGln, also known as muramyl dipeptide), is the minimal bioactive peptidoglycan motif common to all bacteria and the essential structure required for adjuvant activity in vaccines. MDP is recognized by NOD2 (CARD15) a member of the family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.

InvivoGen provides MDP and its derivatives such as L18-MDP and N-glycolyl-MDP which display strong adjuvant activity. For vaccination studies, InvivoGen supplies N-glycolyl-MDP VacciGrade™ (preclinical grade: sterile and endotoxin level

HEK-Blue™ NOD2 Cells are used to validate the functionality of these NOD2 ligands.

CL429TLR2-NOD2 Ligand - Pam2C-conjugated murabutide5 mg
CL429 VacciGrade™TLR2 & NOD2-based adjuvant5 mg
L18-MDPNOD2 Agonist - Muramyldipeptide with a C18 fatty acid chain1 mg
MDPNOD2 Agonist - Muramyldipeptide (L isoform)5 mg
MDP ControlNegative control for MDP - Muramyldipeptide (L-L isomer, inactive)5 mg
MDP RhodamineNOD2 Agonist Rhodamine-labeled - Muramyldipeptide (L isoform)500 µg
M-TriLYSNOD2 Agonist - Synthetic muramyl tripeptide1 mg
MurabutideNOD2 Agonist - Synthetic derivative of muramyldipeptide5 mg
N-Glycolyl-MDPNOD2 Agonist - N-glycolylated muramyldipeptide5 mg
N-Glycolyl-MDP VacciGrade™NOD2 Agonist - N-glycolylated muramyldipeptide
Th1 response
5 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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