NOD2 Agonists

MDP and Derivatives

MDP (MurNAc-L-Ala-D-isoGln, also known as muramyl dipeptide), is the minimal bioactive peptidoglycan motif common to all bacteria and the essential structure required for adjuvant activity in vaccines. MDP is recognized by NOD2 (CARD15) a member of the family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.

InvivoGen provides MDP and its derivatives such as L18-MDP and N-glycolyl-MDP which display strong adjuvant activity. For vaccination studies, InvivoGen supplies N-glycolyl-MDP VacciGrade™ (preclinical grade: sterile and endotoxin level

HEK-Blue™ NOD2 Cells are used to validate the functionality of these NOD2 ligands.

CL429 TLR2-NOD2 Ligand - Pam2C-conjugated murabutide 5 mg
CL429 VacciGrade™ TLR2 & NOD2-based adjuvant 5 mg
L18-MDP NOD2 Agonist - Muramyldipeptide with a C18 fatty acid chain 1 mg
MDP NOD2 Agonist - Muramyldipeptide (L isoform) 5 mg
MDP Control Negative control for MDP - Muramyldipeptide (L-L isomer, inactive) 5 mg
MDP Biotin NOD2 Agonist Biotinylated - Muramyldipeptide (L isoform) 500 µg
MDP FITC NOD2 Agonist FITC-labeled - Muramyldipeptide (L isoform) 500 µg
MDP Rhodamine NOD2 Agonist Rhodamine-labeled - Muramyldipeptide (L isoform) 500 µg
M-TriLYS NOD2 Agonist - Synthetic muramyl tripeptide 1 mg
Murabutide NOD2 Agonist - Synthetic derivative of muramyldipeptide 5 mg
Murabutide control Negative control for Murabutide 5 mg
N-Glycolyl-MDP NOD2 Agonist - N-glycolylated muramyldipeptide 5 mg
N-Glycolyl-MDP VacciGrade™ NOD2 Agonist - N-glycolylated muramyldipeptide
Th1 response
5 mg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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