MDP and Derivatives
MDP (MurNAc-L-Ala-D-isoGln, also known as muramyl dipeptide), is the minimal bioactive peptidoglycan motif common to all bacteria and the essential structure required for adjuvant activity in vaccines. MDP is recognized by NOD2 (CARD15) a member of the family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.
InvivoGen provides MDP and its derivatives such as L18-MDP and N-glycolyl-MDP which display strong adjuvant activity. For vaccination studies, InvivoGen supplies N-glycolyl-MDP VacciGrade™ (preclinical grade: sterile and endotoxin level
HEK-Blue™ NOD2 Cells are used to validate the functionality of these NOD2 ligands.