Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1,2]. In an attempt to enhance the protective activity against bacterial infection, numerous derivatives of MDP have been synthesized. Among them, L18-MDP, a 6-O-acyl derivative with a stearoyl fatty acid, showed the highest activity [3]. In HEK-Blue™ NOD2 cells, L18-MDP was 10 times more efficient than MDP to induce NF-κB activation.


Specificity: NOD2 agonist
Working concentration:
1 - 100 ng/ml
Endotoxin level:
  <0.125 EU/mg
1 mg/ml in water
Formula: C37H66N4O12
Molecular weight: 758.94
Synonym: 6-O-stearoyl-N-Acetyl-muramyl-L-alanyl-D-isoglutamine


• 1 mg L18-MDP
• 2 ml sterile endotoxin-free water

L18-MDP is provided as a sterile white lyophilized powder and shipped at room temperature. Store at -20°C. Upon resuspension, L18-MDP should be aliquoted and stored at -20°C. Product is stable 6 months at -20°C when properly stored. Avoid repeated freeze-thaw cycles.


1. Girardin SE. et al., 2003. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem. 278(11):8869-72.
2. Inohara N. et al., 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.J Biol Chem. 278(8):5509-12.
3. Matsumoto K. et al., 1981. Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice. Infect Immun. 32(2):748-58.



Description MDP with a C18 fatty acid chain
Cat. Codetlrl-lmdp
Unit Size1 mg
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "www.invivogen.com".