M-TriLYS (MurNAc-Ala-D-isoGln-Lys) is a muropeptide released by Lactobacillus salivarus, after digestion of its peptidoglycan (PGN).
Chemically synthesized M-TriLYS is sensed by NOD2 and induces the activation of NF-κB [1].

However, M-TriLYS has been shown to produce the anti-inflammatory cytokine IL-10 and protect mice from colitis, unlike M-TriLYSD-ASN [1]. The opposite effect of both muropeptides may be linked to a differential transport.


Specificity: NOD2 agonist

Working Concentration:
100 ng - 10 µg/ml

Endotoxin level:  EndoFit™ (<0.001 EU/µg)

Synonym: MurNAc-Ala-D-isoGln-Lys

Molecular weight: 620.65

Solubility: 1 mg/ml in water


- 1 mg M-TriLYS provided lyophilized
- 2 ml sterile endotoxin-free water

M-TriLYS is shipped at room temperature. Store lyophilized product at -20˚C.
Lyophilized product is stable 6 months when properly stored.


1. Macho Fernandez E. et al., 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide, Gut, 60: 1050 - 1059.


Recent articles using InvivoGen M-TriLYS



Description NOD2 Agonist - Synthetic muramyl tripeptide
Cat. Codetlrl-mtl
Unit Size1 mg
Price For price or distributor address,
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