Cytokine Reporter Cells

InvivoGen’s cytokine reporter cells comprise an expanding family of engineered cell lines designed to provide a simple, rapid and reliable method to monitor the activation of signaling pathways induced by key cytokines. Cytokine reporter cells enable detection of these biologically active cytokines and can also be used to screen for compounds exhibiting agonist and antagonist activities.

The cytokine reporter cells are derived from different cell types, including the human embryonic kidney 293 and murine B16 melanoma cell lines.

They express an inducible secreted embryonic alkaline phosphatase (SEAP) reporter that can be quantitatively detected using QUANTI-Blue™ or a secreted luciferase (Lucia) that can be readily measured using QUANTI-Luc™.

Cytokine Reporter Cells

Interferon Reporter Cells

B16-Blue™ IFN-α/β CellsMurine B16 melanoma - Type I IFNs reporter cells
HEK-Blue™ IFN-α/β CellsHuman type I IFNs SEAP reporter HEK293 cells
JAK/ISGF3/IRF pathway
HEK-Blue™ IFN-γ cellsHuman IFN-γ SEAP reporter HEK293 cells
JAK/STAT1/IRF pathway
RAW-Blue™ ISG CellsIRF-SEAP-Reporter Cell Line
RAW-Lucia™ ISG CellsIRF-Lucia Luciferase Reporter Cell Line

Interleukin Reporter Cells

HEK-Blue™ IL-1β CellsInflammasome Reporter - IL1-β SEAP reporter HEK293 cells
NF-κB/AP-1 pathway
HEK-Blue™ IL-1R CellsHuman & Mouse IL-1 Sensor Cells
HEK-Blue™ IL-4/IL-13 CellsHuman IL-4 / IL-13 SEAP reporter HEK293 cells
JAK/STAT6 pathway
HEK-Blue™ IL-6 CellsHuman IL-6 Sensor Cells
HEK-Blue™ IL-12 CellsHuman & Mouse IL-12 Sensor Cells
HEK-Blue™ IL-17 CellsHuman & Mouse IL-17 Sensor Cells
HEK-Blue™ IL-18 CellsHuman & Mouse IL-18 Sensor Cells
HEK-Blue™ IL-33 CellsHuman IL-33 Sensor Cells

Tumor Growth Factor Reporter Cells

HEK-Blue™ TGF-β CellsHuman TGFβ SEAP reporter HEK293 cells

Tumor Necrosis Factor Reporter Cells

HEK-Blue™ CD40L CellsHuman CD40L SEAP reporter HEK293 cells
HEK-Blue™ TNF-α CellsHuman TNF-α SEAP reporter HEK293 cells
NF-κB/AP-1 pathway
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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