Toll-like receptor 9 (TLR9) recognizes specific unmethylated CpG motifs prevalent in microbial but not vertebrate genomic DNA leading to innate and acquired immune responses. Microbial DNA immunostimulatory effects can be mimicked by synthetic oligodeoxynucleotides containing these CpG motifs (CpG ODNs).
Three major classes of CpG ODNs have been identified: classes A, B and C, which differ in their immunostimulatory activities. Choose the right class of CpG ODN.
InvivoGen provides a comprehensive collection of TLR9 ligands, which includes:
- stimulatory CpG ODNs (unmodified or labeled) and their control ODNs
- inhibitory ODNs and their control ODNs
- bacterial DNA (single-stranded or double-stranded)
InvivoGen’s TLR9 ligands are high-quality products. Each lot is cell-culture tested and guaranteed contamination-free to avoid TLR9-independent immune responses. HEK-Blue™ TLR9 Cells are used to validate the functionality of these TLR ligands.
VacciGrade CpG ODNs are also available for use as vaccine adjuvants. VacciGrade CpG ODNs are guaranteed sterile and thoroughly tested for the presence of endotoxins.