Ganciclovir (GCV)

Nucleoside analog for in vitro and in vivo cytotoxicity assays

Ganciclovir (GCV) is a guanosine analog used as a prodrug to obtain a suicide effect in cells transfected with the herpes virus thymidine kinase gene (HSV-tk).
HSVTK phosphorylates GCV to GCV-monophosphate which is further converted to GCV-diphosphate and GCV-triphosphate by host kinases. GCV-triphosphate causes premature DNA chain termination and apoptosis. Ganciclovir is approved by the FDA for the treatment of cytomegalovirus (CMV) infections.


CAS number: 82410-32-0

Formula: C9H13N5O4

Molecular weight: 255.2


- 250 mg


Recent articles using InvivoGen Ganciclovir (GCV)



Description DNA synthesis inhibitor
Cat. Codesud-gcv
Unit Size250 mg
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