TRIF inhibitory peptide

Pepinh-TRIF is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction. PepinhTRIF contains the 14 aa that correspond to the sequence of the BB loop of TRIF (FCEEFQVPGRGELH) [1] linked to the cell-penetrating segment of the antennapedia homoedomain (RQIKIWFQNRRMKWKK) [2]. Pepinh TRIF is provided with Pepinh-Control, a control peptide [1].


Working concentration: 5-50 μM
Endotoxin level:

Purity: >95% (HPLC)
Species reactivity:
Human, mouse

• Pepinh-TRIF:
(TRIF homodimerization sequence is underlined)
• Pepinh-Control:

Molecular weights:
• Pepinh-TRIF:     
• Pepinh-Control: 3812


• 2 mg of lyophilized Pepinh-TRIF
• 2 mg of lyophilized Pepinh-Control
• 2x1.5 ml endotoxin-free water

Pepinh-TRIF is provided as a white solid and shipped at room temperature. Store at -20°C. Solid product is stable 1 year at -20°C. Upon resuspension, Pepinh-TRIF should be aliquoted and stored at -20°C. Avoid repeated freeze-thaw cycles. Resuspended product is stable for 6-8 months at -20°C when properly stored.


1. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.
2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.


Recent articles using InvivoGen Pepinh-TRIF



Description TRIF inhibitory peptide
Cat. Codetlrl-pitrif
Unit Size2 mg
Price For price or distributor address,
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