26S proteasome inhibitor

MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome.

This potent inhibitor is used as a tool for disrupting the proteasome-regulated degradation of intracellular proteins, such as IκB. Inhibition of IκB proteasomal degradation by MG-132 leads to the suppression of NF-κB activation [1].

Recent studies suggest that inhibition of the proteasome by MG-132 can induce autophagy by stabilizing Atg protein levels.


Working concentration: 0.2 - 20 µM
CAS number:
Molecular weight:
20 mg/ml in DMSO


• 5 mg MG-132 provided lyophilized

MG-132 is shipped at room temperature. Store lyophilized product at -20°C.
Lyophilized product is stable for 1 year when properly stored.


1. Lee DH, Goldberg AL., 1998. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8(10):397-403.


Recent articles using InvivoGen MG-132



Description 26S proteasome inhibitor - Autophagy activator
Cat. Codetlrl-mg132
Unit Size5 mg
Price For price or distributor address,
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