NLRP3 Inflammasome Inhibitor - IκB-α Inhibitor

Bay 11-7082 is an irreversible inhibitor of TNF-α-induced IκB-α phosphorylation resulting in the inactivation of NF-κB [1]. TNF-α-dependent effects of NF-κB are important for TLR expression and cytokine production [2,3]. Moreover Bay11-7082 selectively inhibit NLRP3 inflammasome activity in macrophages independent of their inhibitory effect on NF-κB activity [4].


Working concentration: 1-10 μM
>99% (HPLC)
CAS number:
Molecular weight:
25 mg/ml in DMSO and 15 mg/ml in ethanol


• 10 mg BAY11-7082


1. Pierce JW. et al., 1997. Novel Inhibitors of Cytokine-induced Ikappa Balpha Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo.J. Biol. Chem., 272: 21096.
2. Phulwani NK. et al., 2008. TLR2 Expression in Astrocytes Is Induced by TNF-{alpha}- and NF-{kappa}BDependent
Pathways. J. Immunol. 181: 3841-3849.
3. Méndez-Samperio P. et al., 2008. Mycobacterium bovis Bacillus Calmette-Guérin Induces CCL5 Secretion via the Toll-Like Receptor 2-NF-{kappa}B and -Jun NTerminal Kinase Signaling Pathways. Clin. Vaccine Immunol.Clin. Vaccine Immunol. 15: 277-283.
4. Juliana C. et al, 2010. Anti-inflammatory Compounds Parthenolide and Bay11-7082 Are Direct Inhibitors of the Inflammasome. J. Biol Chem. 285(13): 9792–9802.



Description IκB-α inhibitor
Cat. Codetlrl-b82
Unit Size10 mg
Price For price or distributor address,
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