MAPK Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor

U0126 is a selective inhibitor of MAP kinase kinases, MEK1 and MEK2 [1].

It acts by inhibiting the kinase activity of MEK1/2 thus preventing the activation of MAP kinases p42 and p44 which are encoded by the erk2 and erk1 genes respectively. MAPK p42/p44 are involved in the signaling cascade triggered by LPS and other ligands through stimulation of the TLRs [2,3,4].

U0126 inhibits MEK1 and MEK2, and thus ERK activation. U0126 can be used to study the role of ERK, a MAPK involved in the induction of autophagy.


Working concentration: 10- 50 µM
CAS number: 109511-58-2
Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene
Molecular weight: 380.5
Solubility: DMSO, 10 mg/ml
Purity: >99% (HPLC, TLC)


• 5 mg


1. Favata MF. et al., 1998. J. Biol. Chem. 273:18623-32.
2. de Franco AL. et al., 1998. Prog Clin Biol Res. 397:119-36.
3. Rabehi L. et al., 2001. Infect Immun. 69:4590-9.
4. Rhee sH. et al., 2004. J Biol Chem. 279:25179-88.



Description MEK1 and MEK2 Inhibitor
Cat. Codetlrl-u0126
Unit Size5 mg
Price For price or distributor address,
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