mTOR Inhibitor and Autophagy Inducer

Rapamycin is an inhibitor of the Ser/Thr protein kinase mTOR (mammalian target of rapamycin), which regulates cell growth and metabolism in response to environmental cues.

Rapamycin is also an inducer of autophagy, as inhibition of mTOR mimics cellular starvation by blocking signals required for cell growth and proliferation [1]. Furthermore, mTOR is a downstream target of PI3K, an important actor in TLR signaling [2]. Indeed, Rapamycin can block TLR2- and TLR4-mediated expression of TNF-α and IL-6 in neutrophils stimulated with Pam3CSK4 or LPS [3].


Working concentration:
- 10-100 nM when used as an inhibitor in the TLR signaling cascade
- 10-500 nM when used to induce autophagy
Purity:>95% (HPLC)
Endotoxin level: <0.125 EU/mg
10 mM in DMSO or 2 mM in ethanol
CAS number:
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, Antibiotic AY 22989; NSC 2260804; Sirolimus
Molecular weight:


• 5 mg Rapamycin

Rapamycin is provided as a solid and shipped at room temperature. Store at -20°C. Solid product is stable 1 year at -20°C. Upon resuspension, Rapamycin should be aliquoted and stored at -20°C. Avoid repeated freeze-thaw cycles. Resuspended product is stable for 3 months at -20°C when properly stored.


1. Jung CH. et al., 2010. mTOR regulation of autophagy. FEBS Lett. 584(7):1287-95.
2. Kuo CC. et al., 2006. Class I and III Phosphatidylinositol 3'-Kinase Play Distinct Roles in TLR Signaling Pathway. J. Immunol., 176: 5943 - 5949.
3. Lorne E. et al., 2009. Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury. Am. J. Respir. Cell Mol. Biol., 41: 237 - 245. 


Recent articles using InvivoGen Rapamycin



Description mTOR inhibitor
Cat. Codetlrl-rap
Unit Size5 mg
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "www.invivogen.com".