Leptomycin B

Nuclear export inhibitor

Leptomycin B, an inhibitor of nuclear export, can be used to study nucleo-cytoplasmic translocation. It has been demonstrated that Leptomycin B can cause the nuclear accumulation of proteins that shuttle between the cytosol and nucleus such as IRAK-1and NLRC5 [1, 2]. The cellular target of Leptomycin B has been identified as CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of proteins [3].


CAS number: 87081-35-4
Formula: C33H48O6
Molecular weight: 540.73
Appearance: Clear, colorless solution
Working concentration: 50-100 nM

Quality control:
- The absence of bacterial contamination (e.g. endotoxins and peptidoglycans) is controlled using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.


• 5 μg Leptomycin B is provided as 930 μL of a 10 μM solution (5.4 μg/ml in ethanol)

Note: This product is packaged under argon gas.

Leptomycin B is shipped at room temperature and should be stored at -20˚C.

STABILITY WARNING: Leptomycin B in any quantity is unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of Leptomycin B, because rapid decomposition and loss of recoverable material will result.


1. Liu G. et al., 2008. Interleukin-1 receptor-associated kinase (IRAK)-1-mediated NF-kB activation requires cytosolic and nuclear activity. FASEB J 22(7): 2285-96.
2. Benko S. et al., 2010. NLRC5 limits the activation of inflammatory pathways. J Immunol. 185(3):1681-91.
3. Kudo N. et al., 1999. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. PNAS. 96(16):9112-7.


Leptomycin B

Description Nuclear export inhibitor
Cat. Codetlrl-lep
Unit Size5 µg
Price For price or distributor address,
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