Multi-PRR Ligands

InvivoGen has developed a series of novel molecules designed to induce potent immune responses through the combined activation of several pattern recognition receptors (PRRs) that trigger different innate immune signaling pathways.

More info on Multi-PRR Ligands

These molecules are agonists for TLR2, TLR7 or both. In addition, some of these ligands have the ability to form complexes with nucleic acids (for example, double-stranded DNA, such as short oligonucleotides or plasmid DNA, or single-stranded RNA) and facilitate their penetration into the cell resulting in their recognition by additional PRRs that sense nucleic acids (e.g. the cytosolic DNA sensors DDX41 and IFI16 and the dsRNA receptors TLR3 and RIG-I/MDA-5).

Dual TLR Agonists

CL401TLR2 & TLR7 Ligand500 µg
Adilipoline™ (CL413)TLR2 & TLR7 Ligand500 µg
CL531TLR2 & TLR7 Ligand500 µg
CL572Human TLR2 & mouse and humanTLR7 Ligand500 µg

TLR Agonists & Nucleic Acid Carriers

AdiFectin™ (CL347)TLR7 Ligand500 µg
CL419TLR2 Ligand500 µg
PamadiFectin™ (CL553)TLR2 & TLR7 Ligand500 µg

TLR & NOD Agonist

CL429TLR2-NOD2 Ligand - Pam2C-conjugated murabutide5 mg
CL429 VacciGrade™TLR2 & NOD2-based adjuvant5 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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