Toll-Like Receptors - TLRs
Toll-Like Receptors (TLRs) are the first identified and best characterized receptors among the signaling pattern recognition receptors (PRRs). They initiate key inflammatory responses and also shape adaptative immunity.
More info on Toll-Like Receptors
All TLRs (10 in humans and 11 in mice) are type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail. They recognize a wide variety of pathogen-associated molecular patterns (PAMPs) from bacteria, fungi, parasites, and viruses, including lipid-based bacterial cell wall components such as lipopolysaccharide (LPS) and lipopeptides, microbial protein components such as flagellin, and nucleic acids such as single-stranded or double-stranded RNA and CpG DNA.
InvivoGen offers a large set of tools to study TLR signaling pathways: TLR expressing cell lines, a comprehensive choice of TLR ligands (agonists and antagonists), TLR antibodies for detection or neutralization, TLR inhibitors such as signal transduction inhibitors and shRNAs, fully sequenced TLR and related genes, and TLR Detection products including PRR signaling reporter plasmids and RT-primers.
