Heavy chain (CH)

pFUSE-CHIg expresses the constant region of the heavy chain (CH) of human, mouse or rabbit immunoglobulin isotypes. They contain a multiple cloning site (MCS) upstream of the constant region to enable the cloning of the variable (VH) region of a given antibody, Fab, scFv.
pFUSE-CHIg plasmids express a large choice of isotypes of the heavy chain constant region:
- Human IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4 and IgM
- Murine IgA, IgD, IgE, IgG1, IgG2A, IgG2B, IgG3 and IgM
- Rabbit IgG

All pFUSE-CHIg plasmids are available with or without the IL2 signal sequence. Addition of this signal sequence allows the secretion of recombinant immunoglobulin generated using Fab or scFv fragments selected from phage display libraries that lack a signal sequence.

pFUSE-CHIg plasmids allow the generation of monoclonal antibodies when used in association with pFUSE-CLIg plasmids. Antibodies generated using pFUSE-CHIg and pFUSE-CLIg can be purified from the supernatant of transfected cells using the appropriate affinity chromatography (i.e. Protein A, Protein G, Protein L, Peptide M, ...)


pFUSE-CHIg-hA1Heavy chain expression plasmid - Human IgA1 Human IgA1 (20 µg)
Human IgA1 with IL2ss (20 µg)
pFUSE-CHIg-hA2m1Heavy chain expression plasmid - Human IgA2 allele m1 Human IgA2m1 (20 µg)
Human IgA2m1 with IL2ss (20 µg)
pFUSE-CHIg-hDHeavy chain expression plasmid - Human IgD Human IgD (20 µg)
Human IgD with IL2ss (20 µg)
pFUSE-CHIg-hEHeavy chain expression plasmid - Human IgE Human IgE (20 µg)
Human IgE with IL2ss (20 µg)
pFUSE-CHIg-hG1Heavy chain expression plasmid - Human IgG1 Human IgG1 (20 µg)
Human IgG1 with IL2ss (20 µg)
pFUSE-CHIg-hG2Heavy chain expression plasmid - Human IgG2 Human IgG2 (20 µg)
Human IgG2 with IL2ss (20 µg)
pFUSE-CHIg-hG3Heavy chain expression plasmid - Human IgG3 Human IgG3 (20 µg)
Human IgG3 with IL2ss (20 µg)
pFUSE-CHIg-hG4Heavy chain expression plasmid - Human IgG4 Human IgG4 (20 µg)
Human IgG4 with IL2ss (20 µg)
pFUSE-CHIg-hMHeavy chain expression plasmid - Human IgM Human IgM (20 µg)
Human IgM with IL2ss (20 µg)


pFUSE-CHIg-mAHeavy chain expression plasmid - Murine IgA Mouse IgA (20 µg)
Mouse IgA (20 µg)
pFUSE-CHIg-mDHeavy chain expression plasmid - Murine IgD Mouse IgD (20 µg)
Mouse IgD with IL2ss (20 µg)
pFUSE-CHIg-mEHeavy chain expression plasmid - Murine IgE Mouse IgE (20 µg)
Mouse IgE with IL2ss (20 µg)
pFUSE-CHIg-mG1Heavy chain expression plasmid - Murine IgG1 Mouse IgG1 (20 µg)
Mouse IgG1 with IL2ss (20 µg)
pFUSE-CHIg-mG2aHeavy chain expression plasmid - Murine IgG2a Mouse IgG2a (20 µg)
Mouse IgG2a with IL2ss (20 µg)
pFUSE-CHIg-mG2bHeavy chain expression plasmid - Murine IgG2b Mouse IgG2b (20 µg)
Mouse IgG2b with IL2ss (20 µg)
pFUSE-CHIg-mG3Heavy chain expression plasmid - Murine IgG3 Mouse IgG3 (20 µg)
Mouse IgG3 with IL2ss (20 µg)
pFUSE-CHIg-mMHeavy chain expression plasmid - Murine IgM Mouse IgM (20 µg)
Mouse IgM with IL2ss (20 µg)


pFUSE-CHIg-catG1Heavy chain expression plasmid - Cat IgG1Cat IgG1 (20 µg)


pFUSE-CHIg-dogG1Heavy chain expression plasmid - Dog IgG1Dog IgG1 (20 µg)
pFUSE-CHIg-dogG2Heavy chain expression plasmid - Dog IgG2Dog IgG2 (20 µg)
pFUSE-CHIg-dogG3Heavy chain expression plasmid - Dog IgG3Dog IgG3 (20 µg)
pFUSE-CHIg-dogG4Heavy chain expression plasmid - Dog IgG4Dog IgG4 (20 µg)


pFUSE-CHIg-rG (rabbit)Heavy chain expression plasmid - Rabbit IgG Rabbit IgG (20 µg)
Rabbit IgG with IL2ss (20 µg)


pFUSE-CHIg-ratG1Heavy chain expression plasmid - Rat IgG1 Rat IgG1 (20 µg)
Rat IgG1 with IL2ss (20 µg)
pFUSE-CHIg-ratG2aHeavy chain expression plasmid - Rat IgG2a Rat IgG2a (20 µg)
Rat IgG2a with IL2ss (20 µg)
pFUSE-CHIg-ratG2bHeavy chain expression plasmid - Rat IgG2b Rat IgG2b (20 µg)
Rat IgG2b with IL2ss (20 µg)
pFUSE-CHIg-ratG2cHeavy chain expression plasmid - Rat IgG2c Rat IgG2c (20 µg)
Rat IgG2c with IL2ss (20 µg)

Rhesus monkey

pFUSE-CHIg-rhG1Heavy chain expression plasmid - Rhesus monkey IgG1 Rhesus monkey IgG1 (20 µg)
Rhesus monkey IgG1 with IL2ss (20 µg)
pFUSE-CHIg-rhG2Heavy chain expression plasmid - Rhesus monkey IgG2 Rhesus monkey IgG2 (20 µg)
Rhesus monkey IgG2 with IL2ss (20 µg)
pFUSE-CHIg-rhG3Heavy chain expression plasmid - Rhesus monkey IgG3 Rhesus monkey IgG3 (20 µg)
Rhesus monkey IgG3 with IL2ss (20 µg)
pFUSE-CHIg-rhG4Heavy chain expression plasmid - Rhesus monkey IgG4 Rhesus monkey IgG4 (20 µg)
Rhesus monkey IgG4 with IL2ss (20 µg)
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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