Coding sequence in expression plasmid

Alias: TMEM173, MITA, MPYS

Stimulator of interferon genes.
Transmembrane protein 173.

STING is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

Several non-synonymous variants of STING have been described in the human population. The prevalent human STING isoform, which contains an arginine at position 232 (R232), is present in ~60% of the human population and therefore, is considered the wild-type [1,2]. The hSTING-WT isoform is preferentially activated by 2’5’linkage-containing cGAMP isomers [3].

This gene is available in pUNO1 expression plasmid selectable with Blasticidin.



   ORF Size: 1140 bp
   Subclone: BspEI - NheI


   Genbank: NM_028261.1
   ORF Size: 1137 bp
   Subclone: AgeI - NheI


- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml


1. Jin L. et al., 2011. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 12(4):263-9.
2. Yi G. et al., 2013. Single nucleotide polymorphisms of human STING can affect Innate immune response to cyclic dinucleotides. PLoS One 8(10):e77846.
3. Gao P. et al., 2013. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154(4):748-62.


Recent articles using InvivoGen STING



Description pUNO1 bearing the human STING gene
Cat. Codepuno1-hstingwt
Unit Size20 µg
Price For price or distributor address,
please select your country


Description pUNO1 bearing the mouse STING gene
Cat. Codepuno1-mstingwt
Unit Size20 µg
Price For price or distributor address,
please select your country
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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