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VACV-70

VACV-70 Naked Unit size Cat. code Docs Qty Price
CDS Agonist
200 µg
tlrl-vav70n
+-
$124.00
VACV-70/LyoVec™ Unit size Cat. code Docs Qty Price
CDS Agonist - LyoVec™ complexed
100 µg
tlrl-vav70c
+-
$135.00

CDS Ligand

VACV-70 is a 70 bp oligonucleotides containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.

VACV-70 oligonucleotide is recognized by IFI16 [1]. VACV-70 is also available complexed with the cationic lipid  transfection reagent LyoVec™ to facilitate its uptake.

VACV-70c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not IFN-inducer [1].

 

1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.

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Specifications

Activity: CDS agonist

Formulation: naked or complexed with the transfection reagent LyoVec™

Control: VACV-70c single-stranded oligonucleotide

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Contents

VACV-70 Naked:

  • 200 µg lyophilized VACV-70 Naked
  • 1.5 ml endotoxin-free water

VACV-70/LyoVec:

  • 100 µg lyophilized VACV-70/LyoVec
    Note: Each vial contains 25 μg of VACV-70 complexed with 50 μg LyoVec™.
  • 10 ml endotoxin-free water

room temperature Product is shipped at room temperature

store Stored at -20°C.

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Citations

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