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VACV-70/ LyoVec™

VACV-70/LyoVec™ Unit size Cat. code Docs Qty Price
CDS Agonist - LyoVec™ complexed
100 µg
tlrl-vav70c
+-
$140.00

CDS Agonist - complexed with transfection reagent

VACV-70 is a 70 bp oligonucleotide containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner. VACV-70 oligonucleotide is recognized by the IFI16 DNA sensor [1]. VACV-70/ LyoVec™ is a formulation of VACV-70 complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its cellular uptake.

InvivoGen also offers VACV-70c (control), a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not inducing interferons (IFNs) [1].

 

Reference:

1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.

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Specifications

Activity: CDS agonist

Formulation: complexed with the transfection reagent LyoVec™

Control: VACV-70c single-stranded oligonucleotide

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Contents

  • 100 µg lyophilized VACV-70/LyoVec™
    Note: Each vial contains 25 μg of VACV-70 complexed with 50 μg LyoVec™.
  • 10 ml endotoxin-free water

room temperature Product is shipped at room temperature

store Store at -20°C

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