VACV-70/ LyoVec™
| VACV-70/LyoVec™ | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
CDS Agonist - LyoVec™ complexed |
100 µg |
tlrl-vav70c |
CDS Agonist - complexed with transfection reagent
VACV-70 is a 70 bp oligonucleotide containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner. VACV-70 oligonucleotide is recognized by the IFI16 DNA sensor [1]. VACV-70/ LyoVec™ is a formulation of VACV-70 complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its cellular uptake.
InvivoGen also offers VACV-70c (control), a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not inducing interferons (IFNs) [1].
Reference:
1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.
Back to the topSpecifications
Activity: CDS agonist
Formulation: complexed with the transfection reagent LyoVec™
Control: VACV-70c single-stranded oligonucleotide
Back to the topContents
-
100 µg lyophilized VACV-70/LyoVec™
Note: Each vial contains 25 μg of VACV-70 complexed with 50 μg LyoVec™. - 10 ml endotoxin-free water
Product is shipped at room temperature
Store at -20°C