VACV-70c control
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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VACV-70c Naked (control) Control for CDS Ligand VACV-70 |
Show product |
200 µg |
tlrl-vav70cn
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VACV-70c/LyoVec™ (control) Control for CDS Ligand VACV-70 - LyoVec™ Complexed |
Show product |
100 µg |
tlrl-vav70cc
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CDS Ligand control
VACV-70c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart, VACV-70, is not IFN-inducer [1].
VACV-70c is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.
VACV-70 is a 70 bp oligonucleotides containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.
VACV-70 oligonucleotide is recognized by IFI16 [1].
1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.
Back to the topSpecifications
Activity: Control for VACV-70 (CDS ligand)
Formulation: naked or complexed with the transfection reagent LyoVec™
Back to the topContents
VACV-70c Naked:
- 200 µg lyophilized VACV-70c Naked
- 1.5 ml endotoxin-free water
VACV-70c/LyoVec:
- 100 µg lyophilized VACV-70c/LyoVec
- 10 ml endotoxin-free water
Product is shipped at room temperature
Stored at -20°C.