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VACV-70c control

VACV-70c Naked (control) Unit size Cat. code Docs Qty Price
Control for CDS Ligand VACV-70
200 µg
tlrl-vav70cn
+-
$128.00
VACV-70c/LyoVec™ (control) Unit size Cat. code Docs Qty Price
Control for CDS Ligand VACV-70 - LyoVec™ Complexed
100 µg
tlrl-vav70cc
+-
$140.00

CDS Ligand control

VACV-70c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart, VACV-70, is not IFN-inducer [1].

VACV-70c is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.

VACV-70 is a 70 bp oligonucleotides containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.

VACV-70 oligonucleotide is recognized by IFI16 [1].

 

1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.

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Specifications

Activity: Control for VACV-70 (CDS ligand)

Formulation: naked or complexed with the transfection reagent LyoVec™

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Contents

VACV-70c Naked:

  • 200 µg lyophilized VACV-70c Naked
  • 1.5 ml endotoxin-free water

VACV-70c/LyoVec:

  • 100 µg lyophilized VACV-70c/LyoVec
  • 10 ml endotoxin-free water

room temperature Product is shipped at room temperature

store Stored at -20°C.

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