HSV-60
| HSV-60 Naked | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
CDS Agonist |
200 µg |
tlrl-hsv60n |
| HSV-60/LyoVec™ | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
CDS Agonist - LyoVec™ complexed |
100 µg |
tlrl-hsv60c |
CDS Agonist
HSV-60 is a 60 bp oligonucleotide containing viral DNA motifs [1]. HSV-60 derives from the herpes simplex virus 1 genome. Transfected HSV-60 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.HSV-60 is recognized by IFI16 [1].
HSV-60 is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.
HSV-60c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not IFN-inducer [1].
1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.
Specifications
Activity: CDS agonist
Formulation: naked or complexed with the transfection reagent LyoVec™
Control: HSV-60c single-stranded oligonucleotide
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HSV-60 Naked:
- 200 µg lyophilized HSV-60 Naked
- 1.5 ml endotoxin-free water
HSV-60/LyoVec:
- 100 µg lyophilized HSV-60/LyoVec
Note: Each vial contains 25 μg of HSV-60 complexed with 50 μg LyoVec™. - 10 ml endotoxin-free water
Product is shipped at room temperature.
Stored at -20°C.