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HSV-60

HSV-60 Naked Unit size Cat. code Docs Qty Price
CDS Agonist
200 µg
tlrl-hsv60n
+-
$124.00
HSV-60/LyoVec™ Unit size Cat. code Docs Qty Price
CDS Agonist - LyoVec™ complexed
100 µg
tlrl-hsv60c
+-
$135.00

CDS Agonist

HSV-60 is a 60 bp oligonucleotide containing viral DNA motifs [1]. HSV-60 derives from the herpes simplex virus 1 genome. Transfected HSV-60 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.HSV-60 is recognized by IFI16 [1].
HSV-60 is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.

HSV-60c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not IFN-inducer [1].

 

1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.

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Specifications

Activity: CDS agonist

Formulation: naked or complexed with the transfection reagent LyoVec™

Control: HSV-60c single-stranded oligonucleotide

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Contents

HSV-60 Naked:

  • 200 µg lyophilized HSV-60 Naked
  • 1.5 ml endotoxin-free water

HSV-60/LyoVec:

  • 100 µg lyophilized HSV-60/LyoVec
    Note: Each vial contains 25 μg of HSV-60 complexed with 50 μg LyoVec™.
  • 10 ml endotoxin-free water

room temperature Product is shipped at room temperature.

store Stored at -20°C.

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Citations

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