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ISD

ISD Naked Unit size Cat. code Docs Qty Price
CDS Agonist
200 µg
tlrl-isdn
+-
$128.00
ISD/LyoVec™ Unit size Cat. code Docs Qty Price
CDS Agonist - LyoVec™ complexed
100 µg
tlrl-isdc
+-
$140.00

CDS Ligand

ISD (interferon stimulatory DNA) is a 45-bp non-CpG oligomer from the Listeria monocytogenes genome.

When transfected into various cell types, including plasmacytoid and conventional DCs, macrophages and murine embryonic fibroblasts, ISD strongly enhances the expression of IFN-β [1].

This ISD-induced response is mediated by the STING-TBK1-IRF3 signaling axis [1-2].

ISD is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.

InvivoGen also provides ISD Control, a non-immunostimulatory single-stranded oligonucleotide with the same sequence as its double-stranded counterpart.

 

References:

1. Stetson DB & Medzhitov R. 2006. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity. 24(1):93-103.
2. Ishikawa H. et al., 2009. STING regulates intracellular DNA-mediated, type I interferondependent innate immunity. Nature. 461(7265):788-92.

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Specifications

Activity: CDS agonist

Working concentration: 100 ng - 10 μg/ml transfected ISD naked or 300 ng - 10 μg/ml ISD/LyoVec™.

Formulation: naked or complexed with the transfection reagent LyoVec™

Control: ISD Control single-stranded oligonucleotide

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Contents

ISD naked:

  • 200 µg lyophilised ISD naked
  • 1.5 ml sterile endotoxin-free water

ISD/Lyovec:

  • 100 µg lyophilised ISD/LyoVec
  • 10 ml sterile endotoxin-free water

room temperature Product is shipped at room temperature.

store Stored at -20°C.

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Citations

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