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Aluminium potassium sulfate
NLRP3 Inflammasome Inducer
Alum crystals has been demonstrated to activate caspase-1 and trigger IL-1β and IL-18 secretion . The alum-induced release of IL-1β in macrophages is dependent on NALP3 and ASC, indicating that alum triggers inflammation through activation of the NALP3 inflammasome .
1. Li H. et al., 2008. Cutting Edge: Inflammasome activation by Alum and Alum’s adjuvant effect are mediated by NLRP3. J Immunol. 181:17-21.
2. Hornung V. et al., 2008. Silica crystals and aluminium salts activate the NALP3 inflammasome through phagosomal destabilization. Nature Immunol. 9:847-856
Working concentration: 10 - 200 µg/ml
CAS number: 7784-24-9
Molecular weight: 474.39
Endotoxin level: <0.125 EU/mg
Solubility: Clear to slightly hazy colorless solution at 0.5 M in H2O
• 1 g Alum crystals (aluminium potassium sulfate)Back to the top