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Alum Crystals

Alum Crystals Unit size Cat. code Docs Qty Price
Aluminium potassium sulfate
1 g
tlrl-alk
+-
$102.00

NLRP3 Inflammasome Inducer

Alum crystals has been demonstrated to activate caspase-1 and trigger IL-1β and IL-18 secretion [1]. The alum-induced release of IL-1β in macrophages is dependent on NALP3 and ASC, indicating that alum triggers inflammation through activation of the NALP3 inflammasome [2].

1. Li H. et al., 2008. Cutting Edge: Inflammasome activation by Alum and Alum’s adjuvant effect are mediated by NLRP3. J Immunol. 181:17-21.
2. Hornung V. et al., 2008. Silica crystals and aluminium salts activate the NALP3 inflammasome through phagosomal destabilization. Nature Immunol. 9:847-856

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Specifications

Working concentration: 10 - 200 µg/ml
CAS number:
7784-24-9
Molecular weight:
474.39
Purity:
≥98.0%
Endotoxin level:
<0.125 EU/mg
Solubility:
Clear to slightly hazy colorless solution at 0.5 M in H2O

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Contents

• 1 g Alum crystals (aluminium potassium sulfate)

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