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Anti-hTNF-α-hIgG4

Anti-hTNF-α-hIgG4 Unit size Cat. code Docs Qty Price
Human TNF-α (adalimumab) antibody - Human IgG4
100 µg
htnfa-mab4
+-
$315.00

Neutralizing human IgG4 monoclonal antibody against human TNF-α

Anti-hTNF-α-hIgG4 is a neutralizing monoclonal antibody featuring the constant region of the human IgG4 isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α).

Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease.

Anti-hTNF-α-hIgG4 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G.

The neutralizing activity of this human IgG4 antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.

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Specifications

ND50 (50% neutralizing dose):  ~ 2 - 5 ng/ml  for 4 ng/ml human TNF-α in HEK-Blue™ TNF-α/IL-1β cells

Clonality: Monoclonal antibody

Application: Neutralization of human TNF-α-induced cellular activation

Specificity: Human TNF-α

Isotype: Human IgG4

Formulation: 0.2 µm filtered solution in 75 mM phosphate buffer with 100 mM glycine, 5% w/v saccharose and stabilizing agents

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Contents

  • 100 µg purified anti-hTNFα-hIgG4 antibody, provided azide-free and lyophilized

room temperature Product is shipped at room temperature.

store Store lyophilized antibody at -20 °C.

stability Lyophilized product is stable for at least 1 year

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