|Anti-hIL-18-IgG||Unit size||Cat. code||Docs||Price|
Neutralizing hIgG1 monoclonal antibody to human interleukin 18
3 x 100 µg
This antibody has been removed from our catalog. However, you may contact us if you wish to order minimal quantities.
Neutralizing IgG monoclonal antibody to human interleukin 18
Anti-hIL-18-IgG is a monoclonal antibody specific for human interleukin 18 (hIL-18). It has been selected for its ability to efficiently neutralize the biological activity of hIL-18. Anti-hIL-18-IgG was generated by recombinant DNA technology.
Interleukin 18 (IL-18; formerly called interferon-γ inducing factor) is a pro-inflammatory cytokine that causes a wide variety of biological effects associated with infection, inflammation and autoimmune processes [1, 2].
More specifically, IL-18 induces IFN-γ production and contributes to T-helper 1 (Th1) cell polarization. IL-18 is produced by macrophages and other cells, as a proprotein which is proteolytically processed to its active form by caspase 1, an enzyme that is activated within the inflammasome multiprotein complex. IL-18 binds to a heterodimeric receptor consisting of IL-18R and IL-18 receptor accessory protein (IL-18RAP). Upon binding, IL-18 activates NF-κB and AP-1 via signaling pathways that involve IRAK and TRAF-6 [3, 4].
Anti-hIL-18-IgG has been produced in Chinese hamster ovarian (CHO) cells and purified by affinity chromatography.
1. Arend W. et al., 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 223:20-38.
2. Dinarello CA. et al., 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 63(6):658-64.
3. Gracie JA. et al., 2003. Interleukin-18. J Leukoc Biol.3(2):213-24.
4. Kojima H. et al., 1998. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. BBRC 244(1):183-6.
Applications: Anti-hIL-18-IgG is a neutralizing antibody, it blocks hIL-18-induced cellular activation.
Target: Natural and recombinant human interleukin 18 (hIL-18).
Clonality: Monoclonal antibody
Isotype: Human IgG1, kappa
Source: CHO cells
Formulation: 0.2 µm filtered solution in a sodium phosphate buffer with saccharose, glycine and stabilizing agents
Purity: Purified by affinity chromatography with protein G
3 x 100 μg purified anti-hIL18-IgG antibody, provided azide-free and lyophilized
Product is shipped at room temperature.
Store lyophilized antibody at -20 °C.