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STING Ligands

Cyclic dinucleotides and xanthenone derivative

Cyclic dinucleotides (CDNs) and the xanthenone derivative DMXAA have been found to bind and activate STING (Stimulator of interferon genes), leading to a potent type I IFN response.

CDNs are important messengers in bacteria affecting numerous responses of the prokaryotic cell.
In mammalian cells, CDNs are potent inducers of the innate immune response.

Thereby, CDNs represent a promising new class of vaccine adjuvants.

To assist your research needs, InvivoGen provides a large collection of CDNs, available in two grades:

  • InvivoGen Standard Grade: purity ≧ 95%, validated using cell-based assays
  • VacciGrade™: sterility guaranteed and endotoxin level < 1 EU/mg, in addition to the above-mentioned criteria

 

 Read our review on STING: Deciphering the STING Paradox

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