Cyclic dinucleotides and xanthenone derivative
Cyclic dinucleotides (CDNs) and the xanthenone derivative DMXAA have been found to bind and activate STING (Stimulator of IFN genes), leading to a potent type I IFN response.
CDNs are important messengers in bacteria affecting numerous responses of the prokaryotic cell.
In mammalian cells, CDNs are potent inducers of the innate immune response.
Thereby, CDNs represent a promising new class of vaccine adjuvants.
To assist your research needs, InvivoGen provides a large collection of CDNs, available in two grades:
- InvivoGen Standard Grade: purity ≧ 95%, validated using cell-based assays
- VacciGrade™: sterility guaranteed and endotoxin level < 1 EU/mg, in addition to the above-mentioned criteria
Read our review on STING: Deciphering the STING Paradox